Abstract
in primary mouse adipocytes from interscapular BAT and inguinal WAT (iWAT). OCR, cyclic AMP and glucose uptake responses were absentminimal from control iWAT cultures but were markedly induced in rosiglitazone-treated cells. Preliminary experiments investigating the in vivo effect of rosiglitazone on -adrenoceptor function was assessed using whole body oxygen consumption and in vivo glucose uptake, which showed a trend for increased -adrenoceptor function in vivo. These studies suggest that cells from iWAT undergo rosiglitazone-induced brite differentiation and have the capacity for increased thermogenesis via UCP1 activation, which may be of significance in vivo.
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