Abstract
Synthetic analogues of atrial natriuretic factor (ANF) have been developed for potential use as therapeutic agents in the treatment of congestive heart failure and hypertension. We studied the effects of 14 intravenous infusions of synthetic ANF (anaritide, human ANF 102–126) on coronary hemodynamics and myocardial energetics in six patients with heart failure. ANF infusion caused no change in coronary blood flow and a fall in coronary vascular resistance from 1.22 ± 0.22 to 1.08 ± 0.18 mm Hg-min/ml ( p < 0.05). Myocardial oxygen and lactate consumption were unchanged from baseline values. Mean arterial pressure fell from 91 ± 4 to 78 ± 3 mm Hg ( p < 0.01), right atrial pressure fell from 10 ± 1 to 8 ± 1 mm Hg ( p < 0.01), pulmonary capillary wedge pressure fell from 21 ± 3 to 16 ± 2 mm Hg ( p < 0.01), heart rate and cardiac index were unchanged, and systemic vascular resistance fell from 1346 ± 130 to 1087 ± 98 dyne-sec/cm 5 ( p < 0.05). We conclude that infusion of ANF in hemodynamically effective doses in patients with heart failure decreases coronary vascular resistance with no change in coronary blood flow or myocardial oxygen or lactate metabolism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
