Effects of atorvastatin serum levels of interleukin-6 and tumor necrosis factor-alpha in patients with acute coronary syndromes

Abstract

Objective To study the effect of atorvastatin on the serum levels of intedeukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)in patients with acute coronary syndromes(ACS),so as to find out the correlation between the changes of IL-6 and TNF-α levels and ACS.Methods 48 ACS patiems who were in accordance with the inclusion criteria.Were randomly divided into atorvastatin group(n=25)and routine treatment group(n=23).The serum levels of IL-6 and TNF-α were measured with radioimmunoassay before and three weeks after treatment respectively.20 healthy physical examines in the same hospitals at the same period were taken as controls.Who did not take any medicine within the two weeks before blood sampling and their serum levels of IL-6 and TNF-α were detectod during physical examination.Results The serum levels of IL.6 and INF-α were obviously higher in the ACS patients than in the control group(P＜0.05).The serum levels of IL-6 and TNF-α in the atorvastatin group after treatment were markedly lower than those before treatment(P＜0.05)which were still higher than those in the comrol group(P＜0.05).There were no obvious changes of the serum IL-6 and INF-α levels in the routine treatment group (P＞0.05).Conclusion The higher the levels of IL-6 and TNF-α the greater the occurrence rate of ACS.Atorvastatin Can reduce the srtum levels of IL-6 and TNF-α in ACS patients,and it has the effects of inhibiting the inflammarion of the site of lesion and improving the endothelial function. Key words: Atorvastatin; Intedeukin-6; Tumor necrosis factor-alpha; Coronary disease