Abstract
Background: Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. Methods: Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Results: Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. Conclusion: It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances.
Highlights
Previous work has indicated that there is an increased risk of coronary heart disease under the menopause as a result of differences in the clotting and fibrinolytic factors, lipid profile and vessel function.[1]
Serum total cholesterol (TC) and low density lipoprotein (LDL) showed no significant differences in any groups
In the positive control rats, vaginal cells showed maturation in response to 17α-ethynylestradiol at a dose of 0.1 mg/kgBW on the third day during the 35 day exposure period. Both the aqueous and ethanolic extracts of the Asparagus racemosus (AR) roots induced significant cornification cells when compared to the Ovariectomized rats group (OVX) group on the fifth day of the exposure period
Summary
Previous work has indicated that there is an increased risk of coronary heart disease under the menopause as a result of differences in the clotting and fibrinolytic factors, lipid profile and vessel function.[1]. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Serum TG of the OAAR and OEAR groups were not significantly different. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances
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