Abstract
This study looked at reducing oxidative stress and free radicals using oral antioxidants. Malondialdehyde (MDA) is widely used as a biomarker for assessing oxidative stress in biomedical fields and in many health problems such as cancer, psychiatry, chronic obstructive pulmonary disease, asthma, or cardiovascular diseases. Lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage and another mechanism involved in oxidative stress. Oxidative stress status was determined using the urinary malondialdehyde test. Preliminary conclusion suggests that oxidative stress in the body can be reduced with appropriate oral anti-oxidants. However future research has to determine to what extent the digestive system and the stress hormonal systems can impact the oxidative status.
Highlights
Oxidative stress is the state of imbalance between the reactive oxygen species (ROS) and the ability of a biological system to detoxify readily the reactive intermediates
Lipid peroxidation is a chain reaction occurring during oxidative stress leading to the formation of various active compounds including propanedial and 4-hyrdoxynonenal (HNE) resulting in the cellular damage
Lipid peroxidation can be initiated by any chemical species that can extract a hydrogen atom from side chain of a polyunsaturated fatty acid (PUFA) which is generally present in the cell membranes
Summary
Oxidative stress is the state of imbalance between the reactive oxygen species (ROS) and the ability of a biological system to detoxify readily the reactive intermediates. Development of oxidative stress because of free oxygen radical generation has been implicated in the pathogenesis of many diseases including Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction and even cancer. ROS and FR are continuously formed in the body of mammals by a partial reduction of oxygen. The superoxide radical (O2ˉ), one of the ROS, is known to be generated in brain. It is involved in the reduction of certain iron complexes including cytochrome C and ferric ethylenediaminetetraacetic acid (Fe3+-EDTA) [1]
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