Abstract
Absorption of trivalent chromium is low. Unbound chromium can form insoluble complexes in the gastrointestinal tract. In this study, effects of a calcium-based antacid or ascorbic acid on 51chromium from chromium chloride were investigated. Rats were dosed with 1 mL of test substance (containing 150 mg calcium carbonate or 10 mg ascorbic acid) or 1 mL water followed by 20 uCi 51chromium chloride. Twenty-four hours after dosing, 51chromium in cumulative urine was higher (p<0.02) in the group dosed with ascorbic acid than in the groups dosed with antacid or water. Accumulation of 51chromium in the kidney, testes, and spleen was lower (p<0.05) in rats dosed with antacid than in those dosed with ascorbic acid or water. These data confirm that absorption of chromium chloride is low and suggest that antacids have a negative effect on chromium absorption from chromium chloride.
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