Abstract
This chapter focuses on the effects of cortisol administration and adrenalectomy on the electrical activity of the brain. The effects of cortisol succinate on the electrical activity of the brain were investigated in rabbits with chronically implanted electrodes in the cortex, dorsal hippocampus, amygdala, septum, preoptic area, ventromedial hypothalamus, posterior hypothalamus, and midbrain reticular formation. Convulsive electrical activity consisting of high-amplitude spikes or delta waves was recorded in the ventromedial hypothalamus and septum, a half to one hour following hormone injection. These seizures either remained localized or spread to other brain areas. Cortisol had no effect on thresholds of arousal produced by reticular formation stimulation. An increase in the amplitude of the hypothalamic potentials evoked by reticular septal or photic stimulation occurred following cortisol administration. Also, the hormone increased the neuronal recovery of the hypothalamic evoked potentials.
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