Abstract
The actions of adrenergic blocking agents were studied, especially as they affect the actions of epinephrine and norepinephrine in term human pregnancy during induced or spontaneous labor. The beta-blocking agent, propranolol, was infused intravenously on 24 occasions in 21 subjects. The influence of propranolol upon the actions of epinephrine was studied in 8 subjects and the effects of propranolol on the actions of norepinephrine were studied in 5 subjects. Three subjects received the alpha-blocking agent, phentolamine, prior to an infusion of norepinephrine. The results demonstrated the ability of propranolol to reverse the usual uterine inhibitory and cardioaccelerator action of epinephrine, the inability of propranolol to block the uterine stimulatory action of norepinephrine, and the ability of phentolamine to block the latter. The results suggest the investigational use of a beta-blocking agent to determine potential inhibitory effects of endogenous epinephrine upon labor.
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