Abstract
The effects of adenosine receptor agonists on plasma NO x − (NO 2 − and NO 3 −) production in mice treated with lipopolysaccharide (LPS) were investigated. NO x − is the stable decomposition product of nitric oxide (NO), which can be measured as a marker of NO production. Injection of the mice with LPS resulted in increased plasma NO x − concentration, reaching a peak after 8 hr (38 times basal level) and then declining slowly. Pretreatment with the adenosine agonists R-phenylisopropyladenosine ( R-PIA), 5′- N-ethylcarboxamidoadenosine (NECA), 5′-( N-cyclopropyl)carboxamidoadenosine (CPCA) and N 6-cyclohexyladenosine (CHA) 1 hr before LPS administration caused a dose-dependent reduction of plasma NO x −1 concentration. The rank order of inhibitory potency was NECA ≥ R-PIA CPCA CHA, which is characteristic of neither A 1 nor A 2 receptors.
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