Abstract
1. 1. The actions of a neurotoxin (VTX-E) purified from hornet ( Vespa mandariana) venom were studied on the neuromuscular junctions of lobster walking leg. 2. 2. VTX-E suppressed reversibly both excitatory and inhibitory postsynaptic potentials without affecting the presynaptic spike. Under the action of the toxin, the potential of the postsynaptic membrane was hyperpolarized with concurrent increase in the membrane conductance. This conductance increase was considered to be due to a permeability increase in chloride ion. 3. 3. The results suggest that the venom of hornet contains a neurotoxin which has an action similar to γ-aminobutyric acid in the crustacean neuromuscular junctions.
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