Effect of Zhibitai capsule in the treatment of elderly coronary artery disease patients with normal lipid

Abstract

Objective To explore the effect of Zhibitai capsule in the treatment of elderly coronary artery disease patients with normal lipid, and to investigate its influence on prognosis. Methods 90 elderly coronary artery disease patients with normal lipid were randomly divided into the control group(n= 30),the treatment group 1(n= 30) and the treatment group 2(n= 30). The control group received routine treatment, once a day for 2 months. The treatment group 1 received the Xuezhikang capsule, once a day for 2 months. The treatment group 2 received the Zhibitai capsule, once a day for 2 months. The expression of inflammatory factors, the level of blood fat, the maintenance rate of sinus rhythm and the incidence rate of embolism before and after treatment were compared among the three groups. Results After treatment,the levels of hs- CRP,IL- 6,TNF-α,TC,TG,LDL- C of the three groups were significantly lower than those before treatment(P< 0.05),and the level of HDL- C was significantly higher than before treatment(P<0.05).The levels of hs- CRP,IL- 6,TNF-α,TC,TG,LDL- Cin the treatment group 2 were significantly lower and the level of HDL- C was significantly higher than the other two goups(P< 0.05). Moreover, the differences between the control group and the treatment group 1 were not statistically significant. The maintenance rate of sinus rhythm of the treatment group 2 was significantly higher and the incidence rate of embolism was significantly lower than the treatment group 1. Conclusion For elderly coronary artery disease patients with normal lipid, the Zhibitai capsule has ideal effect in controlling inflammation, which can delay the progress of atherosclerosis, decrease the major cardiovascular events and better than the Xuezhikang capsule. Key words: Zhibitai capsule; Elderly; Coronary artery disease; Clinical research