Abstract

Studies were carried out to determine the effects of sublethal X-irradiation on the course of Trypanosoma lewisi infection in the white rat. In most experiments the rats were exposed to 300 r total body irradiation 24 hours before inoculation. In one experiment the animals were exposed to a second dose of 200 r total body irradiation on Days 5 or 10 of the infection. Results showed that the single exposure to sublethal irradiation caused a great increase in the parasitemia, an extension of the period of reproduction, and a delay in the appearance of agglutinins. Blood glucose studies showed the development of a hyperglycemia after Day 14 in irradiated and infected animals. A second irradiation dose showed no further effects on the protective mechanisms of the host.

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