Effect of volatile oils extracted from orange peels Citrus sinensis and silver nanoparticles manufactured from it on the concentration of glutathione (GPX) and Levels of oxidative stress Malondialdehyde (MDA) and ‏Lipid ‎peroxides (LPO) in the serum of ma

Abstract

Citrus Citrus fruits are used for the prevention of many chronic diseases such as cancer, diabetes, and cardiovascular diseases. The leaves and fruits of the citrus genus contain antioxidants. The oil of the family plants has uses in folk medicine, The results also showed a significant increase in the concentration of glutathione ‎peroxidase (GPX) when treated with orange peel extract at a concentration of 450 ‎mg/kg and 1 ml/kg of hydrogen peroxide, which amounted to 64.77‎±1.3 ‎ μmol/L ‎Compared to With the treatment that was dosed only with 1 ml/kg of hydrogen ‎peroxide H2O2 as its concentration level was 43.69 ±4.1 μmol/L, there were also ‎significant differences for the treatment when dosed with 0.6 mg/kg with ‎nanosilver and 1 mm/kg of peroxide. The hydrogen peroxide amounted to 57.32 ‎‎±6.2 μmol/L, while the concentration of malondialdehyde (MAD) decreased ‎significantly when treated with orange peel extract at a concentration of 450 mg/kg ‎and 1 ml/kg of hydrogen peroxide, reaching 0.390±0.056 μmol/L (representing the ‎lowest concentration of MAD levels) compared to the treatment dosed with only 1 ‎ml/kg of hydrogen peroxide of 0.757‎‏±‏‎ 0.021‎‏ ‏μmol/L,,,