Abstract
The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist - allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and mean), heart rate, blood flow, and tail blood volume. Stimulation of the TRPA1 ion channel by 2.5% AITC resulted in a diminishing rate of increase in blood pressure and a sharp increase in heart rate while recovering from anesthesia.
Highlights
TRP channels influence numerous important biological processes by controlling the flux of cations across the plasma membrane
The influence of the skin TRPA1 ion channel on the parameters of the cardiovascular system depends on the degree of its activation
A low level of the TRPA1 stimulation enhanced the blood flow, while a higher level of the TRPA1 activation discouraged to increase in arterial pressure and significantly increased the heart rate
Summary
TRP channels influence numerous important biological processes by controlling the flux of cations across the plasma membrane. Alteration in functions of the TRP ion channels can be linked to a number of disorders. The ankyrin (A) transient receptor potential channel TRPA1 is one of the TRP cation channels, distributed throughout the body. Among the channels that conduct currents with a significant (> 20%), Ca2+ fraction under physiological conditions is TRPA1 [1]. TRPA1 channels have preferential permeability to calcium, PCa/PNa ∼7.9 [2]. Ca2+ influx through TRP channels with significant selectivity for Ca2+ could theoretically directly influence the processes in nerves and blood vessels, but there is little experimental evidence in support of this possibility especially in a whole organism
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