Abstract
The effect of thyroparathyroidectomy on the bone mineral response to hyponatremia has been studied in female rats. Four groups: control, adrenalectomized, thyroparathyroidectomized, and adrenalectomized plus thyroparathyroidectomized, were used. The adrenalectomized group developed hyponatremia and a fall in bone sodium. The thyroparathyroidectomized group developed hypocalcemia and no change in serum or bone sodium. The adrenalectomized-thyroparathyroidectomized animals developed hyponatremia, no change in serum calcium from the control values, and no fall in bone sodium. We conclude that thyrocalcitonin or parathyroid hormone is involved in the process causing a fall of bone sodium during a short period of hyponatremia. (Endocrinology 85: 175, 1969)
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