Abstract
The effects of thyroid hormone on cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7α hydroxylase responded the most rapidly and required the lowest dose of T 3. Maximal mRNA levels were reached one hr after T 3 administration and required 10 μg/100g of body weight. These results suggest that the hypocholesterolemic effect of thyroid hormone may be mediated by a primary effect on cholesterol 7α hydroxylase gene expression.
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