Abstract
Motivation and Problem Statement. Thiopental is an anesthetic drug related to the condition of controlling the area of neurological contexts. This study is related to the analysis of effectiveness for the condition of thiopental application on spontaneously hypertensive rats. Methodology. We have evaluated the thiopental induction as the anesthetic agent. The hypertensive rats were selected to administer thiopental in the form of anesthesia. The selection and application of hypertensive strokes are related to the derivation of an inducible model to assess the efficacy for analyzing the ischemic stroke parameters which relate to the human body. We used middle cerebral artery occlusion (MCAO) models related to spontaneous hypertension with the area of examining the complications in ischemic stroke. Results and Conclusion. The study focused on the experimental analysis based on the selection of spontaneously hypertensive rats associated with the incidence of ischemic stroke. Application of thiopental has reported the weak functionality and mechanism on the relaxation of neuronal activity in the case of rat brain. The considered population of the spontaneously hypertensive rats is evaluated based on the condition of effectiveness as well as the duration of the medication effects within the rat brain. Involvement of thiopental in the case of ischemic stroke has provided the area of risk development for high rate of death incidences after occurrence of acute ischemic stroke. A complication in the area of defining neuroprotective actions provides difficulty in drawing an appropriate conclusion of the study.
Highlights
Hypertension was not a treatable disease about half a century ago
Thiopental is commonly known as thiopental sodium used as the anesthesia component, resulting in muscle relaxation
The considered population of the spontaneously hypertensive rats is evaluated based on the condition of effectiveness as well as the duration of the medication effects within the rat brain
Summary
Hypertension was not a treatable disease about half a century ago. Today, it is a prevalent, noncommunicable chronic disease worldwide and could be inhibited by drugs [1]. Patients with hypertension had increased possibility of morbidity and mortality when undergoing anesthesia [2]. It has been found that thiopental is used as an adjunct related to the anesthesia medicines to control the severe stroke complications. During the condition of ventilation and controlled interventions, thiopental sodium has been incorporated as maintaining the area of intracranial pressure increased among the patients of stroke [3]. Thiopental is related to the contraindications of respiratory obstruction as well as the condition of severe shock through the process of medicinal administration. Application of anesthesia in the case of relative context of the human stroke management and effects are yet to be highlighted through the research
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