Abstract
The effect of the trifluoromethyl group on the biological properties of four new isomeric (trifluoromethyl) phenylmercuric chlorides was evaluated with a representative strain of Micrococcus pyogenes (var. aureus ) using the Vincent paper disk modification of the Oxford cup method. This extension of the chemical investigations was motivated by numerous reports in the literature which indicate that there are certain relationships between the physico-chemical properties of organo-metallic compounds and their respective biological activities. The data given reveal some interesting relationships between the chemical structure and antibacterial activity among some of these new organo-mercury compounds. Results with the above method of evaluation and concentrations of 1:1,000 indicate that ortho and para (trifluoromethyl) phenylmercuric chlorides are more effective than the corresponding meta compound. The bis (trifluoromethyl) mercury compound and the meta (trifluoromethyl) phenylmercuric chloride showed activities comparable to that of phenylmercuric chloride.
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