Abstract
ABSTRACT The effect of the thyroid gland on the pseudocholinesterase activity has been investigated. Whereas in female rats the pseudocholinesterase activity is not affected by thyroidectomy, the activity in the liver and serum of male rats is significantly increased after thyroidectomy. In castrated and thyroidectomized male rats, the pseudocholinesterase activity markedly exceeds that of either the castration or the thyroidectomy level; the effects are additive and independent In female rats, thyroidectomy causes an increase of pseudocholinesterase activity in spayed animals. Administration of thyroxine is followed by a decrease in the pseudocholinesterase activity of castrated-thyroidectomized males. It is concluded that the thyroid gland as well as the gonads control the pseudocholinesterase activity: in male rats the relatively low pseudocholinesterase activity is maintained by the combined actions of the gonads and the thyroid gland, whereas in female rats, the thyroid gland does not affect the relatively high enzyme activity induced by the ovarian oestrogens.
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