Abstract
The aim of our study was to compare the effects of the new thrombin inhibitor melagatran on markers of thrombin generation in cord and adult plasma activated with either high or low amounts of tissue factor (TF). The new direct thrombin inhibitor melagatran acts, in contrast to the most frequently administered anticoagulant heparin, independent of the antithrombin content in plasma. In the absence of melagatran adult plasma clotted significantly prior to cord plasma when activated with high amounts of TF, while in contrast clotting of adult plasma is significantly delayed when compared to clotting times of cord plasma under low activation. Under both high and low activation of plasma clotting times dose-dependently increased when melagatran concentrations were successively elevated. Increasing amounts of melagatran resulted in dose-dependently decreased F 1.2 and TAT generation in both cord and adult plasma under both high and low amounts of TF.
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