Abstract
The effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of N-2-fluorenylacetamide (FAA) and N-hydroxy- N-2-fluorenylacetamide (N-OH-FAA) was studied in male and female rats. The administration of 6600 ppm BHT in the diet for 4 wk increased the liver-to-body weight ratio and led to the excretion in the urine of a larger percentage of a single ip dose of either carcinogen. This higher level of excretion was accounted for chiefly by glucuronic acid conjugates. Sulphuric acid esters were decreased. Also lower were the levels of radioactivity in blood, in liver and bound to liver DNA 48 hr after injection of the labelled carcinogen. It is concluded that BHT increases the detoxification metabolites of FAA and N-OH-FAA, and thus lowers the amount of a given dose available for activation reactions.
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