Abstract
The objective of this work was to investigate the effect of hydrocarbon (a-pinene and limonene) andoxygen containing monoterpenes (carvone and terpineole) at 5%w/v in hydroalcoholic mixtures (50% ethanol)on the permeation of ketoprofen across shed snake skin of Python molurus bivittatus. The amount of KPretained in the skin after 8 h of diffusion was determined. It was found that the percutaneous absorption ofketoprofen was enhanced in the presence of the enhancers. The rank order of enhancement ratio for skinpermeation was found to be a-pinene > limonene > carvone > terpinoele. The enhancers also affected theretention of KP in the skin. The rank order of enhancement ratio for skin retention was the same order with skinpermeation experiment. The results indicated that that lipophilicity is an important structural feature formonoterpenes as skin permeation enhancer for a liphophilic drug, ketoprofen. Key Words: Terpenes; Transdermal delivery; Ketoprofen; Shed snake skin
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