Abstract
We studied the effect of partial and complete pituitarectomy in rats on the natural resistance to histamine poisoning and correlated the anatomical changes in the suprarenal gland with the variations in resistance.1 We noted that complete pituitarectomy in rats from 1 to 10 weeks after operation depressed the natural resistance of these animals to histamine poisoning. The M.L.D. was one-fifth to one-third that for normal rats. This decrease in resistance, we found, was associated with involutional changes of the suprarenal gland, such as hemorrhage into or atrophy of the inner zones of the cortex.2 Rats in which the posterior lobe and a large portion of the anterior lobe were removed showed a similar drop in resistance and atrophic changes in the suprarenal cortex occurred, but where a large fragment of the anterior lobe remained no depression in resistance to histamine occurred and the suprarenal glands were normal. We concluded that the drop in natural resistance following pituitarectomy in the rat is p...
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