Abstract

This study was aimed at establishing the effect of total 3-day starvation and that of 28-day food restriction (7-8g standard pellet food daily) on zinc levels in plasma and selected tissues of female Wistar rats. Zinc levels were determined in plasma, red blood cells, liver, and bones. The 3-day starvation led to a statistically significant decrease in plasma, hepatic, and tibia zinc levels in comparison with the respective levels in control animals fed standard pellet food ad libitum. The zinc concentration was also decreased in the liver and bones of rats fed the restricted diet, but they showed unaltered plasma values. No significant change in erythrocyte zinc was observed in either experimental group. The study demonstrated that the 3-day starvation and more prolonged undernutrition exerted marked effects on the organ distribution of zinc. In fast and undernutrition a regulatory system could be supposed that sustains the zinc distribution, according to the tissue priorities.

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