Abstract
In order to examine the effect of sodium hydrodextran sulfate (HDS) on experimental atherosclerosis spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NR) were fed a high-fat diet with and without the drug. Blood samples were collected for 5 months to measure serum levels of cholesterol, triglyceride and clearing factor lipase activity. Effect of HDS on certain blood factors were as follows: 1) HDS inhibited the increase of serum cholesterol levels in rats. 2) HDS did not change the triglyceride concentration. 3) HDS elevated the clearing factor lipase activity. 4) A high-fat diet increased the intimal thickening of arteries in SHR. 5) Intimal thickening of arteries decreased slightly in the HDS treated group.
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