Effect of Shengmai injection on the efficacy and Th1/Th2 balance in children with viral myocarditis

Abstract

Objective To study the effect of Shengmai injection on the efficacy and Th1/Th2 balance in children with viral myocarditis. Methods 126 cases with viral myocarditis were randomly divided into observation group and control group, 63 cases in each group.The two groups were given bed rest, oxygen inhalation, nutrition, myocardial and prevention of complications.On the basis of the above treatment, the observation group was given Shengmai injection, 1 time a day, and 10d for 1 course.The two groups were treated for 2 courses.The serum creatine kinase isoenzyme(CK-MB), troponin I(cTnI), interleukin-4(IL-4), and interferon gamma(IFN-γ) were measured before and after treatment. Results After treatment, the total effective rate of the control group was 81.0%, which was significantly lower than 90.5% of the observation group (χ2=6.78, P<0.05). Before treatment, CK-MB and cTnI of the control group were (142.92±36.51)IU/L, (6.31±0.66)μg/L, respectively, which after treatment were (29.16±2.62)IU/L, (2.71±0.51)μg/L, respectively.Before treatment, the CK-MB and cTnI in the observation group were (140.18±33.14)IU/L, (6.42±0.58)μg/L, respectively, which after treatment were (13.42±1.29)IU/L, (1.62±0.38)μg/L, respectively.The serum levels of CK-MB and cTnI were significantly lower in the two groups after treatment(t=12.306, 14.072, 4.172, 8.334, P<0.05, P<0.01), and the decrease was more significant in the observation group(t=4.118, 2.462, all P<0.05). Before treatment, the IL-4, IFN-γ, IL-4/IFN-γ in the control group were (22.34±9.46)μg/L, (52.19±13.26)μg/L, (0.42±0.12), respectively, which after treatment were (15.26±8.17)μg/L, (60.48±15.23)μg/L, (0.25±0.09), respectively.Before treatment, the IL-4, IFN-γ, IL-4/IFN-γ in the observation group were (23.09±8.84)μg/L, (51.19±14.06)μg/L, (0.45±0.17), respectively, which after treatment were (9.15±5.48)μg/L, (69.42±16.03)μg/L, (0.13±0.05), respectively.The serum IL-4 and IL-4/IFN-γ in the two groups after treatment were significantly lower(t=11.626, 15.306, 3.014, 5.771, P<0.05, P<0.01), and compared with the control group after treatment, which in the observation group decreased significantly(t=4.992, 3.042, P<0.05, P<0.01). The levels of serum IFN-γ in the two groups after treatment were significantly higher(t=2.774, 3.618, P<0.05). Compared with the control group, IFN-γ in the observation group increased more obviously after treatment(t=2.148, P<0.05). Conclusion Shengmai injection in the treatment of children with viral myocarditis can improve the curative effect obviously, which may be related to the improvement of Th1/Th2 balance. Key words: Myocarditis; Shengmai; Cylokines