Abstract
Summary 1.Exogenous serotonin in a dose up to 0.01 mg. per kg. per min. has no significant effect on gastric secretion of acid, but with a dose of 0.04 mg. per kg. per min. the Heidenhain pouch secretion becomes less acid. 2.The stimulus of reserpine to gastric acid secretion does not appear to be mediated by serotonin release. 3.Serotonin in a dose as low as 0.01 mg. per kg. per min. is a potent stimulus to intestinal motility in the dog. This response is characterized by tachyphylaxis and is not blocked by atropine, hexamethonium, or mepyramine. 4.Lysergic acid diethylamide potentiates the intestinal response to serotonin in contrast to an apparent central antagonism.
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