Abstract
Cadmium is a toxic naturally occurring element that affects numerous organ systems in humans, the present study was designed to study the role of bee pollen and selenium against cadmium chloride induced immunotoxicity and Hepatotoxicity in male albino rats. Forty (40) male albino rats were used for the experiment. Group I was intraperitoneal (i.p.) Injected with saline solution, G2 (i.p.) Injected with CdCl2 (1 mg/kg b.w.), G3 were (i.p.) Injected with CdCl2 (1 mg/kg b.w.) and then receive selenium (i.p.) Injection at a dose of (0.5 mg/kg/day). G4 (i.p.) Injected with CdCl2 (1 mg/kg b.w. day by day) and then received bee pollen orally at a dose of (10 g/kg/day). Animals were exposed to treatment once daily for 10weeks. After the last day of treatment, animals were sacrificed and blood samples collected for hematological analysis and serum separated for serum liver enzymes analysis and the liver separated for oxidative stress analysis. Results obtained in this present study revealed a significant increased at (p>0.05) in WBCs, Monocyte , Lymphocyte , Granulocyte and The activities of IgG and IgM, aspartate aminotransferase (AST), alanine transferase (ALT) ,alkaline phosphatase (ALP), (Total- Direct) bilirubin and Malondialdehyde (MAD), while showed a significant decreased at (p>0.05) in albumin and protein, Glutathione (GSH), Superoxide dismutase (SOD) and Catalase (CAT) in group treated with CdCl2 only when compared with normal group. However, Effects of bee pollen and selenium on immunotoxicity and hepatic injury due to cadmium-induced oxidative stress revealed a significant decreased at (p>0.05) in WBCs, Monocyte, Granulocyte and The activities of IgG except Lymphocyte and IgM are not affected also aspartate aminotransferase(AST), alanine transferase (ALT) ,alkaline phosphatase (ALP), (Total- Direct) bilirubin and Malondialdehyde (MAD) showed a significant decreased at (p>0.05), while Total protein, Albumin, Glutathione (GSH), Superoxide dismutase (SOD) and Catalase (CAT) showed a significant increased at (p>0.05) when compared with control group. It is concluded that the bee pollen and selenium have antioxidant properties
Highlights
Toxicity due to overwhelming metals like lead, cadmium, mercury and so on is all around recorded in the literature. (Leonard et al, 2004)
The results are recorded in table1 showed a significant increase in WBCs, Monocyte, Lymphocyte, Granulocyte and the activities of IgG and IgM at (p
W.) after injected with cadmium chloride (CdCl2) which indicated by a significant decrease when compared with control animals and it became near to normal animal except Granulocyte, IgG and IgM not reach to normal animals
Summary
Toxicity due to overwhelming metals like lead, cadmium, mercury and so on is all around recorded in the literature. (Leonard et al, 2004). Friberg et al, (1992) reported that cadmium (Cd) is heavy metal, it known to be present in water, air, food and even cigarette smoke. Several researches have indicated that Cd can stimulate the formation of reactive oxygen species (ROS) and induce damage to various tissues (Alvarez et al, 2007and Thompson and Bannigan, 2008) it is One of the most dangerous toxins for the environment and occupational toxins. It is found in drinking water in food and atmospheric air due to its use in industry (Buchet et al, 1990). Heavy metals are generally immunotoxin, among the many effects displayed (Villanueva et al, 2000) cadmium has been shown to initiate issue in the humoral and cellular immune responses. (Kataranovski et al, 1998; Dan et al, 2000 and Marth et al, 2001)
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