Abstract
Catheter‐based renal nerve ablation (CBRNA) in resistant hypertension (HTN) is associated with long‐term blood pressure (BP) reduction as well as improvement of glucose intolerance, left ventricular hypertrophy, and atrial fibrillation. Evaluation of mechanisms underlying these improvements has been limited by lack of an appropriate animal model. Preliminary work in our lab identified the spontaneously hypertensive rat (SHR) as a potential model for such studies. To validate this model, we recorded ambulatory BP in male SHR (13wk) undergoing renal denervation (RDX: n=8) or sham(n=7) surgery. Within 24hrs, ΔMAP was greater in RDX compared to sham(−11.5±4.3 vs. 1.1±0.9mmHg), but was not sustained at 1 week. Sham animals aged to 21wks were subdivided into RDX (n=4) or sham (n=3) groups and the intervention repeated. ΔMAP was greater in RDX compared to sham within the first day (−28.4±2.3 vs −0.8±1.6mmHg). In contrast to young SHR, ΔMAP persisted after 1 week in older RDX animals vs older shams(−10.5±2.5 vs. −2.2±1.8mmHg). ΔMAP in these animals persisted for the duration of the study. These data demonstrate that older SHR may better model the effects of CBRNA, and may support the hypothesis that interruption of renal afferent nerves is critical in chronically lowering BP. Research Support from AHA 12PRE8190002
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