Effect of rectal diclofenac on incidence of hyperamylasemia and hyperlipasemia after double-balloon enteroscopy

Abstract

To evaluate the efficacy of the prophylactic use of diclofenac in prevention of hyperamylasemia and hyperlipasemia in patients undergoing double-balloon enteroscopy (DBE). One hundred and sixteen patients undergoing peroral DBE were enrolled in the study. Total 121 procedures were performed, in 56 procedures diclofenac sodium 50 mg was administered by rectum 1 h before the peroral DBE (intervention group) and in 65 procedures no medication was given (control group). Serum amylase and lipase levels were measured before and 4 h, 24 h after the procedure.At 4 h after DBE the incidence rates of hyperamylasemia and hyperlipasemia in intervention and control groups were 33.9%, 38.5% (P>0.05) and 21.4%, 36.9% (P>0.05), respectively. At 24 h after DBE, the incidence rates of hyperamylasemia and hyperlipasemia in intervention and control groups were 19.6%, 24.6% (P>0.05) and 10.7%, 15.4% (P>0.05), respectively. Mild acute pancreatitis developed in one patient and gastrointestinal hemorrhage occurred in another patient.Hyperamylasemia and hyperlipasemia is common and transient after double-balloon enteroscopy, and rectal administration of diclofenac sodium cannot effectively reduce the incidence. Key words: Hyperamylasemia; Lipase; Double-balloon enteroscopy