Abstract
The efficacy of recombinant human interferon α B/D in experimental HSV-1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-α B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P=0.021), whereas natural mouse interferon was inactive. Combination of acyclovir with Hu-IFN-α B/D had an additive effect.
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