Abstract
Background One of the major challenges in long term psychopharmacological management of schizophrenia is development of side effects, most notably tardive dyskinesia. The problem of tardive dyskinesia (TD) was more prevalent with the use of first generation anti psychotic medications; the second generation drugs are believed to have a lesser propensity to cause such movement disorder. However, once TD develops the treatment options are rather limited, with the possible exception of Clozapine usually modestly effective in about half of the patients. Thus there exists a need for searching alternative therapeutic methods for tackling this vexing problem.
Highlights
One of the major challenges in long term psychopharmacological management of schizophrenia is development of side effects, most notably tardive dyskinesia
Aim The aim was to find out if use of quetiapine is associated with a decrease in tardive dyskinesia, in young patients of schizophrenia who developed TD on their first anti psychotic medication. Materials and methods This was an open label observation study involving six male patients diagnosed as suffering from acute schizophrenia for which they had been prescribed anti psychotic medications, namely haloperidol and Risperidone
The dyskinetic movements were rated with Abnormal Involuntary Movements Scale
Summary
One of the major challenges in long term psychopharmacological management of schizophrenia is development of side effects, most notably tardive dyskinesia. The problem of tardive dyskinesia (TD) was more prevalent with the use of first - generation anti psychotic medications; the second generation drugs are believed to have a lesser propensity to cause such movement disorder. Once TD develops the treatment options are rather limited, with the possible exception of Clozapine - usually modestly effective in about half of the patients. There exists a need for searching alternative therapeutic methods for tackling this vexing problem
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