Abstract

Background: To examine the effect of Qianlie Xiaozheng Tang (QLXZT), a Chinese herbal decoction, on treating castration resistant prostate cancer
 (CRPC).
 Materials and Methods: A total of 70 men with CRPC were recruited and randomly allocated into treatment groups (treated with QLXZT and
 conventional therapy) or control group (treated with conventional therapy) for 12 weeks treatment. Primary endpoint was serum prostate specific
 antigen (PSA) concentration. Secondary endpoints included patients' quality of life measured by Functional Assessment of Cancer Therapy-Prostate
 questionnaire, and prostate cancer-specific anxiety assessed by Memorial Anxiety Scale for Prostate Cancer.
 Results: After a 12-week treatment, the PSA level in control group rose remarkably from 45.3 ± 17.0 to 76.0 ± 56.7 ng/ml (P=0.0015). By contrast,
 the PSA level in treatment group did not increase significantly (P>0.05). The scores of Functional Assessment of Cancer Therapy-Prostate in each
 domain changed significantly (P

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