Abstract
BackgroundOsseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteoanabolic effects. This study aimed to investigate the effects of PTH and corticotomy, both under traction force, on osseointegrated implants.MethodsFour implants—two in each hemimandible—were placed in each of the three study mongrels. Each mongrels were designated as control, normal dose PTH (PTH-1), and high dose PTH (PTH-2) groups, with each groups further subdivided into non-surgery implant and surgery implant. After osseointegration, mechanical force with NiTi closed coil springs (500 g) was applied around each implants. Corticotomy was performed around one of four implants in each mongrels. Parathyroid hormone was administered locally on a weekly basis for 20 weeks. Clinical movement of the implants were evaluated with the superimposed 3D- scanned data, bone- microarchitectural and histologic examinations.ResultsSuperimposition analysis showed continuous movement of the non-surgery implant of PTH-1 group. Movement was further justified with lowest bone implant contact (adjusted BIC; 44.77%) in histomorphometric analysis. Upregulation of bone remodeling around the implant was observed in the normal dose PTH group. In the surgery implants, the remarkably higher adjusted BIC compared to the non-surgery implants indicated increased bone formation around the implant surface.ConclusionThe results indicate that the catabolic and anabolic balance of osseointegrated implants in terms of bone remodeling can be shifted via various interventions including pharmacological, surgical and mechanical force.Clinical relevanceUpregulated bone remodeling by PTH and corticotomy under continuous mechanical force showed the possible implications for the movement of osseointegrated dental implant.
Highlights
Osseointegrated implants are considered as clinically non-movable
Clinical relevance: Upregulated bone remodeling by Parathyroid hormone (PTH) and corticotomy under continuous mechanical force showed the possible implications for the movement of osseointegrated dental implant
This study demonstrated that implant movement may be feasible with intermittent PTH injection and application of mechanical force
Summary
Osseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteo‐ anabolic effects. This study aimed to investigate the effects of PTH and corticotomy, both under traction force, on osseointegrated implants. Kim et al BMC Oral Health (2020) 20:315 osseointegrated dental implants, clinically considered static, may impose limitations to orthodontic treatment. The obliteration of PDL makes ankylosed teeth rigid. In such a sense, implants are similar to ankylosed teeth in that they are immobile, ankylosed teeth treatment methods may be applied to study the possible movement of implants. Surgery is one treatment method for ankylosed teeth in orthodontic treatment [4] Surgical approach such as dentoalveolar distraction osteogenesis has been attempted for canine retraction in orthodontic treatment [5]. Corticotomy and pharmacologic agent administration were applied to clarify their effects on implant movement
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