Abstract
Changes in the distribution of biogenic amines in the brain were produced by intraperitoneal injection of psychotropic drugs — reserpine (80 μg/100 g) and chlorpromazine (300 μg/100 g) — during chronic experiments on rats. Under these conditions reserpine reduced the endogenous RNA polymerase activity of types I and II of the rat brain cell nuclei on average by 61 and 34%, and chlorpromazine did so by 32 and 38% respectively. In a cell-free system reserpine and chlorpromazine in concentrations of 0.1 and 1 mM had no effect on the RNA-systhesizing activity of isolated rat brain cell nuclei. It is suggested that the action of psychotropic drugs on the genetic apparatus may be mediated through, either a decrease in cyclic AMP production or inhibition of RNA-synthesizing activity.
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