Abstract
The behavior of C57BL/6, CBA, and BALB/c mice in an “open field” test was studied after administration of phenazepam in doses of 0.05, 0.075, and 0.1 mg/kg and of sydnocarb in doses of 6, 12, and 24 mg/kg. The initial response to emotional stress was characterized by greatest motor activity (MA) in C57BL/6 mice and minimal in BALB/c mice. Phenazepam lowered MA in C57BL/6 mice proportionally to the dose. A biphasic effect of the tranquillizer was found in BALB/c mice. Depending on the dose, sydnocarb stimulated MA of C57BL/6 mice, did not effect the behavior of CBA mice, and in a dose of 24 mg/kg, it increased MA of BALB/c mice.
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