Effect of preoperative neutrophil/lymphocyte ratio on the prognosis of patients with prostate cancer

Abstract

Objective To explore effect of preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis of patients with prostate cancer. Methods A total of 51 cases died included in our hospital as the died group, also included 124 patients survival patients served as survival group. Preoperative total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), albumin, white blood cell (WBC), neutrophil count, lymphocyte count, Gleason score, and NLR were collected. Receiver operating characteristic (ROC) curve was drawn. The function of the index on prognosis was evaluated. Results The average age was 74.0(9) years in the died group, and 73.6(11.0)years in the survival group. Gleason score was 8~10. The patients were followed up for 10~36 months with a median follow-up time of 23 months. No significant differences in albumin and Gleason score were found between death and survival groups (P>0.05). However, the other major indexes had significant differences between two groups (P<0.01). NLR area under curve(AUC) was 0.835. The NLR boundary value was 2.84, which was higher than the critical value of patients with poor prognosis. Conclusions NLR can predict the prognosis of patients with malignant prostate cancer as auxiliary index. Patients with NLR>2.83 had poor prognosis. Key words: Neutrophils; Lymphocytes; Prostatic neoplasms; Prognosis