Abstract
BackgroundDespite ample evidence of continuing preoperative aspirin to improve coronary artery bypass surgery outcomes, practice for the routine continuation of preoperative aspirin is inconsistent due to concern for increased postoperative bleeding. The purpose of this study was to investigate preoperative aspirin use and its effect on postoperative bleeding after off-pump coronary artery bypass grafting (OPCABG).MethodologyThis cohort study involved patients (n = 74) who underwent OPCABG at a single center between August 2017 and January 2018. After considering the inclusion and exclusion criteria, the patients were divided into two groups: one (n = 37) received tablet aspirin 75 mg till the day of the surgery, and for the other group (n = 37) aspirin was stopped five days before the surgery. Postoperative bleeding was recorded in both groups. After considering preoperative, intraoperative, and postoperative variables, statistical analysis was performed.ResultsThere was no significant difference between the two groups concerning peroperative and postoperative variables. In addition, no significant difference was observed between the two groups in chest tube drainage at one, two, three, twenty-four, forty-eight, and seventy-two hours (p = 0.845, 0.126, 0.568, 0.478, 0.342, and 0.717, respectively). No significant difference was seen in the transfusion requirement of blood and fresh frozen plasma (FFP).ConclusionsContinuation of preoperative aspirin till the day of the surgery is neither associated with an increase in chest tube drainage, reoperation for bleeding complications nor transfusion of blood and FFP.
Highlights
Coronary artery disease (CAD) is among the leading causes of morbidity and mortality worldwide, and its prevalence and adverse impact continue to increase [1]
There was no significant difference between the two groups concerning peroperative and postoperative variables
No significant difference was seen in the transfusion requirement of blood and fresh frozen plasma (FFP)
Summary
Coronary artery disease (CAD) is among the leading causes of morbidity and mortality worldwide, and its prevalence and adverse impact continue to increase [1]. The mechanisms of aspirin that confer protection against myocardial infarction and postoperative graft thrombosis contribute to increased bleeding complications during cardiac surgery. It is a long-established practice to stop aspirin a few days before any surgery including CABG. It is associated with a reduction in postoperative ischemia and cardiac, cerebrovascular, gastrointestinal, and renal complications [3]. Our study aimed to observe the effect of preoperative aspirin use on postoperative bleeding after off-pump coronary artery bypass grafting. The purpose of this study was to investigate preoperative aspirin use and its effect on postoperative bleeding after off-pump coronary artery bypass grafting (OPCABG)
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