Abstract
IT HAS been reported from our laboratories that the intravenous administration of triiodothyronine (T-3) to a myxedematous patient was followed by a marked rise in oxygen consumption within seven hours. The intravenous administration of triiodothyronine in comparable, or even greater doses, to intact dogs has not in our hands been observed to cause any acute elevation in oxygen consumption. However, during the course of studies in dogs designed to determine the effect of triiodothyronine on the oxygen consumption of kidney tissue, it was observed that the intravenous administration of triiodothyronine to animals receiving a continuous infusion of phosphate produced a marked and rapid increase in oxygen consumption and death from what appeared to be a thyroid storm. These observations suggested that a phosphate load enhanced the action of this thyroid hormone.
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