Abstract
Skeletal mineral uptake and resorption and renal parenchymal content of calcium, phosphorus and magnesium were measured in normocalcemic and hypercalcemic rats after infusions of phosphate, magnesium and combinations of the two. Phosphate infusion decreased plasma calcium by 20–30%, increased renal calcium by 50–300% and had no effect on skeletal turnover. In hypercalcemic but not normocalcemic rats, renal phosphorus and magnesium were also increased. Magnesium infusion in normocalcemic rats had no effect on plasma calcium but caused a 17% decrease in renal calcium. Plasma inorganic phosphorus was increased by 35% with no change in renal phosphorus. Renal magnesium was increased only 35% despite a 4-fold increase in plasma magnesium. Similar effects were observed in hypercalcemic rats except that no decrease in renal calcium and no increase in plasma inorganic phosphorus occurred. No direct effect of magnesium infusion on skeletal turnover was evident. Combined infusions resulted in two effects which were...
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