Abstract
The reported incidence of osteoporosis is lower in countries in which the Mediterranean diet predominates, and this apparent relationship may be mediated by the phenolic compounds present in olive oil. The objective of this study was to determine the effect of phenolic extracts from different varieties of extra-virgin olive oil (Picual, Arbequina, Picudo, and Hojiblanca) on the differentiation, antigenic expression, and phagocytic capacity of osteoblast-like MG-63 cells. At 24 h of treatment a significant increase in phosphatase alkaline activity and significant reductions in CD54, CD80, and HLA-DR expression and in phagocytic activity were observed in comparison to untreated controls. The in vitro study performed has demonstrated that phenolic compounds from different extra virgin olive oil varieties can modulate different parameters related to osteoblast differentiation and function.
Highlights
Osteoporosis affects elderly men and women world-wide and is becoming increasingly frequent as people live longer
The alkaline phosphatase (ALP) activity of osteoblast-like cells cultured in osteogenic medium was significantly increased (p
The expression of CD54, CD80, and HLA-DR on osteoblast-like cells was reduced by treatment with phenolic extracts from every EVOO variety studied
Summary
Osteoporosis affects elderly men and women world-wide and is becoming increasingly frequent as people live longer. Olive oil is considered the main fat source in this dietary model and is highly appreciated for its characteristics and nutritive properties. The biological properties of phenolic compounds in extra virgin olive oil (EVOO) are well documented [2] and are likely to account for its positive effects. These compounds have been found to reduce the risk of coronary disease [3], cancer [4,5], atherosclerosis, and stroke [6], among other diseases.
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