Abstract

Abstract Phenethyl alcohol inhibits the growth of Ehrlich II B and L cells at concentrations greater than 0.2 per cent. Removal of the inhibitor within one hour allows recovery of most of the cells. The first biochemical change noted was a decrease in the DNA content of the cells at time periods where the cell number, content of RNA, and protein remained unchanged or were increasing. Chromosome preparations and Feulgen staining revealed that there was a loss of mitotic figures, chromosomes, and Feulgen staining material from the nucleus. Visual observations and radioactivity measurements suggested a solubilization of the DNA of treated cells. The labeling of nuclei and DNA by tritiated thymidine was inhibited and a decrease in the strength of chain-chain interaction in phenethyl alcohol treated DNA was observed.

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