Abstract
1. 1. Treatment of localized myocardial ischemia depends upon addition of arterial blood by way of intercoronary arterial communicacations. 2. 2. Pentaerythritol tetranitrate adds 0.81 cc. per minute to the ischemic circumflex area of the dog heart. 3. 3. Amyl nitrite adds 0.98 cc. per minute to the ischemic circumflex area of the dog heart. 4. 4. Alcohol decreases intercoronary flow by 1.93 cc. per minute. 5. 5. Increased intercoronary flow resulting from drug action is temporary. 6. 6. Addition of 0.81 cc. per minute as produced by pentaerythritol tetranitrate did not reduce mortality or infarct size following test coronary artery ligation in a series of twentyone experiments.
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