Abstract
Intravenous injection of ovine prolactin (1 mg/kg) into normal dogs resulted during the first hour in a transient decrease in the plasma free fatty acid (FFA) concentration, which was followed by a significant increase by the third hour and thereafter. The effect of prolactin injection (2 mg/kg) on the preceding day on FFA turnover and oxidation in the postabsorptive state was determined in unanesthetized normal dogs by the intravenous infusion of 14C-palmitate. The elevated plasma FFA levels were associated with an increased rate of FFA production and removal from the plasma. The amount of plasma FFA carbon which was oxidized rapidly to respiratory CO2, as determined by the exhaled 14CO2, was increased in the prolactin- treated dogs, but there was no change in the percentage of the FFA carbon taken up which was oxidized to CO2. (Endocrinology 88: 1349,1971)
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