EFFECT OF OPIOID PEPTIDE ANALOG ON ANIMAL BEHAVIORAL RESPONSES UNDER EXPERIMENTAL CONDITIONS ALLOXANE DIABETES MELLITUS

Abstract

The aim is to assess the effect of the opioid peptide dalargin on the behavioral responses of laboratory animals under the conditions of experimental alloxane diabetes mellitus. Material and methods. The experiment was performed on nonlinear white male rats weighing 280-290 g. Laboratory animals were divided into several groups: 1 – control group, which received water for injection daily by intraperitoneal administration (control), 2 – animals with alloxane diabetes mellitus; group 3 – diabetic individuals treated with dalargin for 21 days intraperitoneally at a dose of 100 mkg/kg/day starting one month after alloxan administration. Diabetes mellitus was modeled by intraperitoneal administration of alloxane to pre-starved animals for 24 hours at a dose of 100 mg/kg once (dose worked out in preliminary studies). Assessment of the severity and dynamics of individual behavioral acts, as well as the level of emotional-behavioral reactivity of animals, was carried out using psychopharmacological tests: "Raised cruciform labyrinth" and "Dark light chamber." Results. When dalargin was administered to animals under the conditions of alloxane diabetes mellitus, an increase in motor activity and cognitive activity was noted, which indicated a decrease in anxiety that was observed during the development of experimental diabetes mellitus. Conclusion. Based on the results obtained from the study of the effect of the opioid peptide dalargin on the behavioral responses of laboratory animals under the conditions of experimental alloxane diabetes mellitus, it was found that the investigational drug has psychocorregative, antidepressant and anxiolytic effects.