Abstract
In doses of 0.4 and 4 mg/kg nicotine reduced the noradrenalin (NA) content in the rat brain for 2 h. The greatest decrease in NA was observed in the period of hyperkinesia evoked by nicotine in a dose of 4 mg/kg. A further injection of the same dose of nicotine 30 min later did not give rise to hyperkinesia and did not induce, any further decrease in NA. In a dose of 4 mg/kg given 4 and 20 h after reserpine (5mg/kg) nicotine reduced the NA level and caused the appearance of hyperkinesia. Injection of nicotine (4 mg/kg) 25 min after amphetamine (5 mg/kg) did not significantly lower the NA level. Liberation of NA in the brain tissues is evidently an important central effect of nicotine and it shares a common mechanism with the effect of amphetamine.
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