Abstract
Quantitative recording of motor activity in dogs showed that benactyzine (2 mg/kg intramuscularly) led to an increase in this activity which persisted for 2–3 h. The effect of benactyzine was abolished by intramuscular injection of galanthamine in a dose of 3 mg/kg. The most effective of the neuroleptics and tranquilizers studied was perphenazine. Chlorpromazine and diazepam not only did not abolish the hyperactivity induced by benactyzine, but they also caused the animals' condition to worsen. A further increase in hyperactivity was observed after diazepam and haloperidol. Levomepromazine abolished hyperactivity in some animals but potentiated other symptoms induced by benactyzine. It is postulated that motor hyperactivity produced by benactyzine is connected with anticholinergic mechanisms; the use of the drug for blocking the action of neuroleptics with marked cholinolytic properties is thus contraindicated.
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