Effect of nerve growth factor in the treatment of elderly patients with cerebral hemorrhage and its effect on the nervous function

Abstract

Objective To investigate the effect of nerve growth factor in the treatment of senile cerebral hemorrhage and its effect on the nerve function. Methods According to the digital table, 90 elderly patients with cerebral hemorrhage were randomly divided into observation group and control group, 45 patients in each group.The control group was given conventional treatment for cerebral hemorrhage.The observation group was injected mouse nerve growth factor based on the control group.The efficacy of the two groups after treatment, nerve function defect score(NIHSS) before and after treatment changes and simple type Fugl-Meyer motor function score(FMA) were compared. Results The total effective rate of the observation group after treatment was 93.33%, which was higher than 73.33% of the control group, the difference was statistically significant(χ2=6.480, P=0.010). Before treatment, the NIHSS scores of the two groups had no statistically significant difference (t=0.333, P=0.739). After treatment, the NIHSS score of the observation group was (6.49±7.02)points, which was lower than (11.01±8.65)points of the control group, the difference was statistically significant(t=2.721, P=0.007). Before treatment, the FMA scores of the two groups had no statistically significant difference (t=0.198, P=0.198). Compared with the control group, the FMA score of the observation group after treatment was significantly higher, the difference was statistically significant(t=3.222, P=0.001). Conclusion Rat nerve growth factor in the treatment of elderly patients with cerebral hemorrhage can effectively improve the patients' neurological deficits and activities of daily living, the clinical efficacy is significant, it is worthy of clinical application. Key words: Cerebral hemorrhage; Nerve growth factor; Treatment outcome