Abstract
Pharmacologists at Georgetown University, Washington, DC examined functional synaptic maturation in striatal medium spiny neurons from neonatal rats exposed to antiepileptic drugs (AED) with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proapoptotic action (levetiracetam).
Highlights
Pharmacologists at Georgetown University, Washington, DC examined functional synaptic maturation in striatal medium spiny neurons from neonatal rats exposed to antiepileptic drugs (AED) with proapoptotic action and without proapoptotic action
Protection from experimental seizures in small, laboratory animals is the backbone of development of new potentially effective and less toxic antiepileptic drugs, beginning with the introduction of phenytoin in 1937
Various laboratory methods to elicit seizures have been employed in the testing of new drugs, and major advances were made in the mid 1900s, in the pharmacology department at the University of Utah, under the direction of Louis S Goodman, Ewart A Swinyard, Dixon M Woodbury and others
Summary
Researchers at University of Fukui, Japan analyzed the relation between EEG abnormalities and PDD or ADHD, and assessed the clinical utility of EEG in the differential diagnosis of these disorders. Paroxysmal discharges at the frontopolar-frontal brain regions and background EEG abnormalities were detected preferentially in the PDD group expressing persistence or hypersensitivity, whereas central-temporal discharges were detected preferentially in the ADHD group expressing impulsivity. Dysfunction of specific brain areas associated with EEG abnormalities might explain characteristics of PDD and ADHD symptoms.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
