Abstract
Germfree rats on either a 1 % cholesterol diet for 21 days or a 1 % cholesterol −0.1 % cholic acid diet for 17 days exhibited serum and liver cholesterol levels which were 50 % to 100 % higher than those of comparable conventional controls. Administration of neomycin to rats on a 1 % cholesterol −0.1 % cholic acid diet increased serum cholesterol levels by 100 % and liver cholesterol levels by 50 % in the conventional animals but was without effect on the high cholesterol levels of the germfree group. Neomycin did not affect the fecal bile acid or sterol output of germfree rats but significantly reduced the fecal bile acid loss of the conventional group.
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